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Containment Isolators:
CESCO offers both rigid and flexible containment isolators, to meet the particular customer needs for containment performance, delivery and time to deployment, and investment. Rigid isolators typically achieve a containment performance level of <1 microgram/cubic meter, while flexible solutions fall in the range of 1 to 10 microgram/cubic meter. Some examples of containment isolator solutions are as follows:
R&D Containment Isolator:
R&D Containment Isolator - Designed for the containment of potent powdered compounds during various functions and process steps involved with injectable formulations and filling. Experience with such projects shows that operator protection significantly below 1 microgram/m3 TWA, can be achieved when defined operating procedures are followed. This multi-functional lab scale development isolator provides integrated zones within one single negatively-pressurized chamber to allow processes including mixing, magnetic stirring, weighing, homogenization, drying, and filling under a strict temperature and pressure control system. In order to provide a unidirectional zone for hand filling of vials, the area to the right hand side of the isolator is fitted with a terminal HEPA filter for constant 45 ft/min downflow of clean air.
Milling, Mixing, and Reactor Charging Isolators:
Milling Interface Isolator - Designed to enable operators to manipulate and mill hazardous materials in a contained manner, protecting both the operator and the surrounding environment.
Mixing Isolator - Designed for charging pre-weighed potent powdered compounds into the liquid held in the integrated mixing tank. This tank is fully welded into the base of the isolator.
Reactor Charging Isolator - Designed for the charging or transfer of potent powdered or liquid compounds into reactors, vessels or similar receivers.
Experience with such projects show operator protection significantly below 1 microgram/m3
TWA can be achieved when defined operating procedures are followed.
Filter-Tray Dryer Isolator:
Filter-Tray Dryer Isolator - Designed to give total operator and environmental protection during potent API slurry filtration, drying and product transfer between the dryer and the receiving container. From the API slurry created within the remote reactor, the unit is designed to filter crystals from the API liquid into wet-cake form. The cake is then placed on trays and dried in the integrated tray dryer in the back wall of the isolator. Once dried, the powder is then weighed on the appropriate integrated balance and placed into bags. The bags of dried API are removed from the isolator under high containment by placing them into the RTP Beta containers. This fully packaged system is provided with solvent recovery and mother liquor tanks for the filtration process as well as an integrated vacuum system. The tray dryer has heated shelving allowing consistent drying as well as a packaged temperature controlled unit for total system control and flexibility.
Drum Filling Isolator:
Drum Filling Isolator - Designed for packaging out potent compounds into a fiber drum. The primary containment is provided by an inflatable seal and continuous liner system, followed by secondary containment provided by the negatively-pressurized barrier isolator. The system and sequences are fully automated.
Flexible Containment Isolators:
 
Flexible Containment Isolators - Flexible solutions are a rapidly growing product range. They provide containment standards better than can be achieved with laminar downflow booth technology, and compare favorably with rigid isolator systems. As well as providing high levels of operator safety, flexible isolators benefit from relatively short lead times, and lower costs than airflow booths or rigid isolator systems. Due to their light duty construction, flexible isolators are often applied to experimental or R&D applications, where speed of deployment and operator safety are a priority. Process applications can be met by the flexible isolator ra,nge through the addition of features such as rapid transfer ports (RTP's) and rigid work platforms. Containment performance is in the range of 1 to 10 microgram/cubic meter, depending on design, equipment integration, and standard operating procedures.
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